Cambridge Open Engage home
What is Cambridge Open Engage?
How to Submit
Browse
About
News [opens in a new tab]

A broadly applicable Diels-Alder based Synthesis of Ketamine related Arylcyclohexylamines

09 November 2022, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Herein we report the synthesis of both aryl derivatives of ketamine and aryl derivatives of ketamine’s major metabolites hydroxynorketamine (HNK), norketamine (NK) and dehydronorketamine (DHNK) via a microwave-assisted Diels-Alder reaction to form the substituted cyclohexane core structure. Starting with aryl acrylic esters as dienophiles and siloxybutadienes as diene counterparts, a wide range of substituted arylcyclohexylamines was obtained after several modification steps of the initial Diels-Alder products.

Keywords

Ketamine
HNK
Diels-Alder

Supplementary materials

Title
Description
Actions
Title
Supplementary Information
Description
Experimental Procedures and Spectra
Actions

Comments

Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.

Version History

Nov 09, 2022 Version 1

Metrics

902
619
0
Views
Downloads
Citations

License

CC logo
CC
BY logo
BY
NC logo
NC
ND logo
ND
The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2022-xf1l9
D O I: 10.26434/chemrxiv-2022-xf1l9 [opens in a new tab]

Funding

Ministerium für Kultur und Wissenschaft des Landes Nordrhein-Westfalen
322 – 8.03.04-127491
Bundesministerium für Wissenschaft, Forschung und Wirtschaft
50WB2128

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

Share