Mechanics of Dynamic and Deformable DNA Nanostructures

02 November 2022, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


In DNA nanotechnology, DNA molecules are designed, engineered, and assembled into arbitrary-shaped architectures with predesigned functions. Static DNA assemblies often have delicate designs with structural rigidity to overcome thermal fluctuations, whose design strategies have been studied extensively. Dynamic structures reconfigure in response to external cues. Such transformational mechanisms have been explored to create dynamic nanodevices for environmental sensing, payload delivery, and other applications. However, the precise control of reconfigurable dynamics has been a challenge due partly to flexible single-stranded DNA connections between moving parts. Deformable structures are special dynamic constructs with deformation on double-stranded parts and single-stranded hinges during reconfiguration. These structures often have better controls in programmed deformation. However, related deformability and mechanics, as well as deformation mechanisms are not well understood or documented. In this review, we summarize the development of dynamic and deformable nanostructures from the mechanics perspectives. We present deformation mechanisms such as single-stranded DNA hinges with lock-and-release pairs, jack edges, helicity modulation, and external loading. Theoretical and computational models are discussed for understanding the deformations and mechanics, including commonly used elasticity theory, finite element method, and coarse-grained molecular dynamics models. Other special models are also introduced. We elucidate the pros and cons of each model and recommend design processes based on the models. The design guidelines should be useful for those who have limited knowledge in mechanics as well as expert DNA designers. After presenting unique applications, we conclude with current challenges in dynamic and deformable structures and outlook for the development of the field.


DNA self-assembly
DNA nanostructures
mechanical deformation
structural properties


Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.