A Purification-Free Method for the Synthesis of Thiazolium Salts Using P2S5-Py2 Complex or P4S10

03 November 2022, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

An expedient method to prepare thiazolium salts using the P2S5-Py2 complex or P4S10 has been studied. A variety of thiazolium salts can be rapidly accessed by the clean reaction between readily available α-formamido ketones and these reagents. The pure thiazolium salts are obtained via simple filtration followed by salt metathesis with sodium tetrafluoroborate or sodium tetraphenylborate. The method is suitable for a variety of substituents on the heterocycle. The use of these reagents confers a practical advantage over the use of Lawesson’s reagent, making the purification of the thiazolium salt straightforward.

Keywords

N-heterocyclic carbenes
Thiazolium
P2S5-Py2

Supplementary materials

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SI for A Purification-Free Method for the Synthesis of Thiazolium Salts Using P2S5-Py2 Complex or P4S10
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