A Concise Total Synthesis of (±)-Stepharine and (±)-Pronuciferine

31 October 2022, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

We herein report a concise total synthesis of (±)-stepharine and (±)-pronuciferine using readily available reagents as the starting materials. This synthesis features a three-component Catellani reaction/Au-catalyzed 6-exo-dig cyclization for the assembly of 1-methylene-THIQ scaffold and an oxidative dearomatization for constructing spiro-cyclohexadienone scaffold.

Keywords

Stepharine
Pronuciferine
1-Methylene-tetrahydroisoquinoline
Catellani reaction
Total synthesis

Supplementary materials

Title
Description
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Title
Supporting Information for A Concise Total Synthesis of (±)-Stepharine and (±)-Pronuciferine
Description
Supporting Information for A Concise Total Synthesis of (±)-Stepharine and (±)-Pronuciferine
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