Visible-light promoted N-aminoalkylation of quinazolinones

31 October 2022, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


A visible-light promoted direct coupling of quinazolinones and simple alkylamides to approach highly functionalized N-aminoalkyl quinazolinones was reported. This protocol serves as a highly efficient and straightforward strategy for N-aminoalkylation transformation of quinazolinones employing tert-Butyl peroxybenzoate as an oxidant in combination with visible-light irradiation conditions. This process features mild reaction conditions and tolerance for a wide range of functional groups. Synthetically important and highly functionalized N-aminoalkyl quinazolinones were afforded high levels of yields (up to 86% yield).


N-H fuctionalization


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