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NHPyOx as a Chem-Bio Model for the Synergistic Discovery of Novel Ligands Facilitating Pharmaceutical Science

25 October 2022, Version 1

Abstract

Amino-pyridine-oxazoline (NH-PyOx) was conceived as a proof-of-concept of a chem-bio model (CBM) for function-oriented synergistic optimization. It culminated in the discovery of novel ligands showing much better performance in Hayashi-Miyaura coupling or antifungal performance than that of PyOx and boscalid, respectively.

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Supplementary materials

NHPyOx as a Chem-Bio Model for the Synergistic Discovery of Novel Ligands Facilitating Pharmaceutical Science
NHPyOx as a Chem-Bio Model for the Synergistic Discovery of Novel Ligands Facilitating Pharmaceutical Science

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Version History

Oct 25, 2022 Version 1

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License

CC logo BY logo NC logo ND logo
The content is available under CC BY NC ND 4.0 CreativeCommons.org [opens in a new tab]

DOI

10.26434/chemrxiv-2022-lw3s9
D O I: 10.26434/chemrxiv-2022-lw3s9 [opens in a new tab]

Funding

National Natural Science Foundation of China
21772094, 21977049
the Research Foundation of Guizhou University
202016

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) declare that they have sought and gained approval from the relevant ethics committee/IRB for this research and its publication.

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Publication

This content is an early or alternative research output and has not been peer-reviewed at the time of posting.