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Enantioselective hydroalkoxylation of 1, 3-dienes via Ni-catalysis

18 October 2022, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

As an advance in hydrofunctionalization, we herein report that alcohols add to 1,3-dienes with high regio- and enantioselectivity. Using a Ni-DuPhos, we access enantioenriched allylic ethers. Through the choice of solvent-free conditions, we control the reversibility of C-O bond formation. This work showcases a rare example of methanol as a reagent in asymmetric synthesis

Keywords

hydroalkoxylation
diene
alcohol
enantioselective
Ni-catalysis

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Version History

Oct 18, 2022 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2022-h9x2q
D O I: 10.26434/chemrxiv-2022-h9x2q [opens in a new tab]

Funding

Beijing Natural Science Foundation
2222024
National Key Research and Development Program of China
2021YFA1401200
National Science Foundation
CHE-1956457

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

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