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A new approach to migraines - A review of rimegepant; its merits, synthesis, and pharmacological characteristics

28 September 2022, Version 1
Review
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Migraines in the modern day represent a significant problem, however, the current treatment options come with significant risks. This paper reviews rimegepant, its pharmacological characteristics, and possible synthetic pathways, focusing on ease of synthesis, green chemistry, and scalability. The review reveals a biocatalytic approach to be a promising candidate for industrial scale-up with relatively mild conditions.

Keywords

rimegepant
migraines
biocatalysis
stereochemistry
stereoselective synthesis
CGRP receptor antagonists
transaminase

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Version History

Sep 28, 2022 Version 1

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The content is available under CC BY NC 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2022-9d5l4
D O I: 10.26434/chemrxiv-2022-9d5l4 [opens in a new tab]

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

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