Using metal-organic frameworks to confine liquid samples for nanoscale NV-NMR

16 September 2022, Version 2
This content is a preprint and has not undergone peer review at the time of posting.


Atomic-scale magnetic field sensors based on nitrogen vacancy (NV) defects in diamonds are an exciting platform for nanoscale nuclear magnetic resonance (NMR) spectroscopy. The detection of NMR signals from a few zeptoliters to single molecules or even single nuclear spins has been demonstrated using NV-centers close to the diamond surface. However, fast molecular diffusion of sample molecules in and out of nanoscale detection volumes impedes their detection and limits current experiments to solid-state or highly viscous samples. Here, we show that restricting diffusion by confinement enables nanoscale NMR spectroscopy of liquid samples. Our approach uses metal-organic frameworks (MOF) with angstrom-sized pores on a diamond chip to trap sample molecules near the NV-centers. This enables the detection of NMR signals from a liquid sample, which would not be detectable without confinement. These results set the route for nanoscale liquid-phase NMR with high spectral resolution.


nitrogen vacancy center
metal-organic framework
nuclear magnetic resonance
quantum sensing

Supplementary materials

Supplementary Information
Supplementary Information: Using metal-organic frameworks to confine liquid samples for nanoscale NV-NMR


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