Organic Chemistry

A 1-pot synthesis of the SARS-CoV-2 Mpro Inhibitor Nirmatrelvir, the key ingredient in Paxlovid



A newly devised route to the Pfizer drug nirmatrelvir is reported that reduces the overall sequence to a 1-pot process and relies on a commercially available, green coupling reagent, T3P. The overall yield of the targeted material, isolated as its MTBE solvate, is 53%.


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Supplementary material

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Supporting Information
Optimization of reaction protocols and NMR, HRMS, and HPLC data of isolated compounds.