Organic Chemistry

Preparation of new bicyclo[2.1.1]hexane compact modules: an opening towards to novel sp3-rich chemical space

Authors

Abstract

Among the valuable saturated bicyclic structures incorporated in newly developed bio-active compounds, bicyclo[2.1.1]hexanes are playing an increasingly important role, while being still underexplored from a synthetic accessibility point of view. Here, we disclose an efficient and modular approach toward new 1,2-disubstituted bicyclo[2.1.1]hexane modules. Our strategy is based on the use of photochemistry to access new building blocks via [2+2] cycloaddition. The system can readily be derivatized with numerous transformations, opening the gate to sp3-rich new chemical space.

Content

Thumbnail image of Preparation of new bicyclo[2 1 1]hexane compact modules, an opening towards to novel sp3-rich chemical space_review.pdf

Supplementary material

Thumbnail image of Preparation of new bicyclo[2 1 1]hexane compact modules, an opening towards to novel sp3-rich chemical space_SI.pdf
Preparation of new bicyclo[2.1.1]hexane compact modules: an opening towards to novel sp3-rich chemical space
Among the valuable saturated bicyclic structures incorporated in newly developed bio-active compounds, bicyclo[2.1.1]hexanes are playing an increasingly important role, while being still underexplored from a synthetic accessibility point of view. Here, we disclose an efficient and modular approach toward new 1,2-disubstituted bicyclo[2.1.1]hexane modules. Our strategy is based on the use of photochemistry to access new building blocks via [2+2] cycloaddition. The system can readily be derivatized with numerous transformations, opening the gate to sp3-rich new chemical space.