Control on dissipative kinetics reveals the entropically-dominated essence of interlocked molecular machines

05 September 2022, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


The operation of nanomachines is fundamentally different from that of their macroscopic counterparts. In particular, the role of solvent is critical, yet rarely associated with machine functionality. Here we study a minimal model of one of the most advanced molecular machines, to gain control on its operation by engineering components and the employed solvent. Operation kinetics was modulated over more than four orders of magnitude, and could be fine-tuned. Leveraging solvent properties, it was possible to realize multiple cycles of the molecular machine operation while monitoring it. Our work expands the capabilities of acid-base powered molecular machines, contributing to the development of systems that leverage solvent properties to expand their functionality.


molecular machine
supramolecular chemistry

Supplementary materials

Supplementary information
Experiemental procedures and supporting data.


Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.