Analytical Chemistry

Microfluidic quantum sensing platform for lab-on-a-chip applications

Authors

  • Robin Derek Allert Technical University of Munich, Department of Chemistry, Lichtenbergstr. 4, 85748 Garching b. München, Germany ,
  • Fleming Bruckmaier Technical University of Munich, Department of Chemistry, Lichtenbergstr. 4, 85748 Garching b. München, Germany ,
  • Nick Ruben Neuling Technical University of Munich, Department of Chemistry, Lichtenbergstr. 4, 85748 Garching b. München, Germany ,
  • Fabian Alexander Freire-Moschovitis Technical University of Munich, Department of Chemistry, Lichtenbergstr. 4, 85748 Garching b. München, Germany ,
  • Kristina Song Liu Technical University of Munich, Department of Chemistry, Lichtenbergstr. 4, 85748 Garching b. München, Germany ,
  • Claudia Schrepel LightFab GmbH, Talbotstr. 25, 52068 Aachen, Germany ,
  • Philip Schätzle University of Freiburg, Department of Sustainable Systems Engineering (INATECH), Emmy-Noether-Str. 2, 79110 Freiburg, Germany ,
  • Peter Knittel Fraunhofer Institute for Applied Solid State Physics, Tullastr. 72, 79108 Freiburg, Germany ,
  • Martin Hermans LightFab GmbH, Talbotstr. 25, 52068 Aachen, Germany ,
  • Dominik Benjamin Bucher Technical University of Munich, Department of Chemistry, Lichtenbergstr. 4, 85748 Garching b. München, Germany & Munich Center for Quantum Science and Technology (MCQST), Schellingstr. 4, 80799 München, Germany

Abstract

Lab-on-a-chip (LOC) applications have emerged as an invaluable tools in physical and life sciences. However, LOC applications require extensive sensor miniaturization to leverage their full potential. In recent years, novel atom-sized quantum sensors have enabled measurements of temperature, electric and magnetic fields on the nano- to microscale. Nevertheless, the technical complexity of both disciplines has so far impeded an uncompromising combination of LOC and quantum sensors. Here, we present a fully integrated microfluidic platform for solid-state spin quantum sensors, such as the nitrogen-vacancy (NV) center in diamond. Our platform fulfills all technical requirements, such as fast spin manipulation, enabling full quantum sensing capabilities, biocompatibility, and easy adaptability to arbitrary channel and chip geometries. To illustrate the vast potential of quantum sensors in LOC devices, we demonstrate various NV center-based magnetic resonance experiments for chemical analysis in our microfluidic platform. We anticipate our microfluidic quantum sensing platform as a novel tool for electrochemistry, high throughput reaction screening, bioanalytics or organ-on-a-chip, and single-cell studies.

Content

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