Abstract
Solvent accessibility has been extensively used to characterize and predict the chemical properties of surface residues of soluble proteins. In contrast, there is not yet a widely accepted quantity of the same dimension for the study of lipid accessible residues of membrane proteins. In this work, we propose that lipid accessibility, defined in a similar way to the solvent accessibility, can be used to well characterize the lipid accessible residues of membrane proteins. Moreover, we developed a deep learning-based method, ProtRAP (Protein Relative Accessibility Predictor), to predict the relative lipid accessibility and relative solvent accessibility of residues from a given protein sequence, which can infer which residues are likely accessible to lipids, accessible to solvent, or buried in the protein interior in one run.
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Supplementary Information, including Materials and Methods, Supplementary Tables, and Supplementary Figures.
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ProtRAP Server
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The website has the ProtRAP Server, which can predict the relative lipid accessibility and relative solvent accessibility of each residue for a given protein sequence.
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