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Abstract
The practical and facile difluorocarbene-triggered cycloaddition reaction of enaminones was developed, that delivered 2,2-difluoro-2,3-dihydrofurans with broad substrates scope. Notably, the reaction proceeded smoothly without any extra additive. The readily available sodium chlorodifluoroacetate (ClCF2CO2Na, SCDA) played as difluorocarbene precursor in this transformation through DMF-promotion. Moreover, it is proved that the 2,2-difluoro- 2,3-dihydrofuran derivatives exposed potential antiproliferative activity against human tumour cells HeLa, MCF7 and HepG2.
