Synthesis of Some Heterocyclic Compounds Using Cyanoacetohydrazide as Versatile Precursor

24 August 2022, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

This study reviewed the use of cyanoacetohydrazide as versatile precursor for synthesis of some heterocyclic compounds, as it contains five different functional groups ( cyano group, No. 1, active methylene group, No. 2, carbonyl group, No. 3, amido group, No. 4 and hydrazine group, No.5 ) The reviewed reactions were classified according to the active centers of cyanoacetohydrazide involved. Accordingly, they are divided into 12 classes in which heterocycles was obtained via the utility of the following functional groups: a - groups No. 1, 2, b - groups No. 1,5, c - groups No. 2, 3 , d - groups No. 2,4 , e - groups No. 2,5 , f- groups No. 3,5 , g- groups No. 4,5 , h- groups No. 1,2,5, i- groups No. 1,4,5, j- groups No. 2,4,5, k- groups No. 1,2,4,5, l-groups No. 2,3,4,5 .This review covers literature up to 2021.

Keywords

Cyanoacetohydrazides
Cyanoacetic acid hydrazide
Heterocycles
Cyclization

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