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A Au(I)-Catalyzed Alkoxylation-Induced Double Aldol Condensation Approach to 2,2'-Spirobi[indene] Derivatives

08 August 2022, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

An efficient gold(I)-catalyzed intramolecular alkoxylation/double aldol condensation cascade cyclization strategy to synthesize 2,2'-spirobi[indene] derivatives has been developed. The scope of this strategy was examined by using a batch of synthetic alkynone substrates and a possible mechanism was proposed.

Keywords

Au(I)-Catalyzed
intramolecular alkoxylation/double aldol
cascade cyclization
2'-spirobi[indene] derivatives

Supplementary materials

Title
Description
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Title
A Au(I)-Catalyzed Alkoxylation-Induced Double Aldol Condensation Ap-proach to 2,2'-Spirobi[indene] Derivatives
Description
An efficient gold(I)-catalyzed intramolecular alkoxylation/double aldol condensation cascade cyclization strategy to synthesize 2,2'-spirobi[indene] derivatives has been developed. The scope of this strategy was examined by using a batch of synthetic alkynone substrates and a possible mechanism was proposed.
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Now Published

Gold(I)-Catalyzed Tandem Intramolecular Methoxylation/Double Aldol Condensation Strategy Yielding 2,2′-Spirobi[indene] Derivatives [opens in a new tab]
Jingfu Zhang, Sen Zhang, Zhixing Ding, Anbin Hou, Jiayue Fu, Hongwei Su, Maosheng Cheng, Bin Lin, Lu Yang, Yongxiang Liu journal article
Organic Letters , Volume 24, Issue 37
Online publication date: Sep 14, 2022

Version History

Aug 08, 2022 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2022-g1n35
D O I: 10.26434/chemrxiv-2022-g1n35 [opens in a new tab]

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) declare that they have sought and gained approval from the relevant ethics committee/IRB for this research and its publication.

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