Organic Chemistry

A Au(I)-Catalyzed Alkoxylation-Induced Double Aldol Condensation Approach to 2,2'-Spirobi[indene] Derivatives

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Abstract

An efficient gold(I)-catalyzed intramolecular alkoxylation/double aldol condensation cascade cyclization strategy to synthesize 2,2'-spirobi[indene] derivatives has been developed. The scope of this strategy was examined by using a batch of synthetic alkynone substrates and a possible mechanism was proposed.

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Supplementary material

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A Au(I)-Catalyzed Alkoxylation-Induced Double Aldol Condensation Ap-proach to 2,2'-Spirobi[indene] Derivatives
An efficient gold(I)-catalyzed intramolecular alkoxylation/double aldol condensation cascade cyclization strategy to synthesize 2,2'-spirobi[indene] derivatives has been developed. The scope of this strategy was examined by using a batch of synthetic alkynone substrates and a possible mechanism was proposed.