Total Synthesis of Ginkgolide C and Formal Synthesis Ginkgolides A and B

04 August 2022, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


Ginkgolides are diterpenes isolated from ginkgo biloba that exhibit strong PAF antagonistic activity as well as other interesting neuroprotective properties. These natural products possess a compact, highly oxygenated hexacyclic structure with two adjacent quaternary carbon centers, an unusual tert-butyl group, and up to twelve contiguous stereogenic carbon centers. The molecular architecture of ginkgolides, coupled with their remarkable biological profile, continues to be a source of fascination but also presents a formidable challenge for chemical synthesis. Herein, we reported the first total synthesis of ginkgolide C and the formal syntheses of ginkgolides A and B. The key to achieving these syntheses is a careful orchestration of carbon-carbon bond formation, guided by the compact nature of the ginkgolide structure.


Total Synthesis
Natural products
PAF antagonist

Supplementary materials

Total Synthesis of Ginkgolide C and Formal Synthesis of Ginkgolides A and B
Supporting Information


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