Quinuclidine-mediated electrochemical oxidation of glycopyranosides provides C3-ketosaccharides with excellent selectivity. The method is a versatile alternative to Pd-catalyzed oxidation, and to photochemical oxidation, and is complementary to the TEMPO-mediated C6-selective oxidation. Contrary to the electrochemical oxidation of methylene and methine groups, the reaction does not require oxygen.
Site-selective Electrochemical Oxidation of Glucosides
01 August 2022, Version 1
This content is a preprint and has not undergone peer review at the time of posting.