Organic Chemistry

Water-soluble Bioisosteres of the ortho-substituted Phenyl Ring

Authors

Abstract

Water-soluble analogues of the ortho-substituted phenyl ring were developed. Replacement of the phenyl ring in bioactive compounds with 2 oxabicyclo[2.1.1]hexanes in many cases improved solubility, reduced lipophilicity, enhanced metabolic stability, and most importantly – retained bioactivity.

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Title and authors were added to SI.

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Supplementary material

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