Cambridge Open Engage home
What is Cambridge Open Engage?
How to Submit
Browse
About
News [opens in a new tab]

Water-soluble Bioisosteres of the ortho-substituted Phenyl Ring

30 June 2022, Version 2
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Water-soluble analogues of the ortho-substituted phenyl ring were developed. Replacement of the phenyl ring in bioactive compounds with 2 oxabicyclo[2.1.1]hexanes in many cases improved solubility, reduced lipophilicity, enhanced metabolic stability, and most importantly – retained bioactivity.

Supplementary materials

Title
Description
Actions
Title
SI
Description
Supporting Information
Actions

Comments

Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.

Now Published

2-Oxabicyclo[2.1.1]hexanes as saturated bioisosteres of the ortho-substituted phenyl ring [opens in a new tab]
Aleksandr Denisenko, Pavel Garbuz, Nataliya M. Voloshchuk, Yuliia Holota, Galeb Al-Maali, Petro Borysko, Pavel K. Mykhailiuk journal article
Nature Chemistry , Volume 15, Issue 8
Online publication date: Jun 05, 2023

Version History

Jun 30, 2022 Version 2

Version Notes

Title and authors were added to SI.

Metrics

2,827
5,764
2
Views
Downloads

License

CC logo
CC
BY logo
BY
The content is available under CC BY 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2022-tln0p-v2
D O I: 10.26434/chemrxiv-2022-tln0p-v2 [opens in a new tab]

Funding

European Research Council
101000893

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) declare that they have sought and gained approval from the relevant ethics committee/IRB for this research and its publication.

Share