Decarboxylative Cross-Coupling: A Radical Tool In Medicinal Chemistry

20 June 2022, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


Carboxylic acids, the most versatile and ubiquitous diversity input used in medicinal chemistry for canonical polar bond constructions such as amide synthesis, can now be employed in a fundamentally different category of reaction to make C–C bonds by harnessing the power of radicals. This outlook serves as a user guide to aid practitioners in both the design of syntheses that leverage the simplifying power of this disconnection and the precise tactics that can be employed to enable them. Taken together this emerging area holds the potential to rapidly accelerate access to


Decarboxylative Cross-Coupling
Medicinal Chemistry
Radical Retrosynthesis


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