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Abstract
The catalytic enantioselective synthesis of α-chiral alkenes and alkynes represents a powerful strategy for rapid generation of molecular complexity. Herein, we report a transient directing group facilitated site-selective palladium-catalyzed reductive Heck-type hydroalkenylation and hydroalkynylation of alkenylaldehyes using alkenyl and alkynyl bromides, respectively, allowing for construction of a stereocenters at the δ position with respect to the aldehyde.
Supplementary materials
Title
Supporting Info
Description
Experimental procedures, characterization data for new compounds, copies of NMR spectra and SFC chromatograms, X-ray crystallographic data
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Title
3ak_CIF
Description
Crystallographic information file for compound 3ak
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