Reporting SERS enhancement factor: molecular surface coverage standards by grazing-incidence X-ray fluorescence.

31 May 2022, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


We used reference-free grazing incidence X-ray fluorescence to measure the density of four thiol Raman-active molecules assembled on gold surfaces. This value is needed to reliably quantify the number of molecules contributing to the SERS signal in a plasmonic substrate in the effort to standardize the enhancement factor calculation and such molecules constitute suitable probes for benchmarking SERS sensors.


enhancement factor
molecular quantification
SERS analytes
reference-free GIXRF


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