Advances in nano- and microscale NMR spectroscopy using diamond quantum sensors

26 May 2022, Version 2
This content is a preprint and has not undergone peer review at the time of posting.


Quantum technologies have seen a rapid developmental surge over the last couple of years. Though often overshadowed by quantum computation, quantum sensors show tremendous potential for widespread applications in chemistry and biology. One system stands out in particular: the nitrogen-vacancy (NV) center in diamond, an atomic-sized sensor allowing the detection of nuclear magnetic resonance (NMR) signals at unprecedented length scales down to a single proton. In this article, we review the fundamentals of NV center-based quantum sensing and its distinct impact on nano- to microscale NMR spectroscopy. Furthermore, we highlight and discuss possible future applications of this novel technology ranging from energy research, material science, or single-cell biology, but also associated challenges of these rapidly developing NMR sensors.


Nuclear magnetic resonance spectroscopy
quantum sensing
Nitrogen-Vacancy Centers
Single-cell biology
Quantum Sensors
Analytical chemistry
physical chemistry
ESR spectroscopy
Electron spin resonance
surface science
drug screening


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