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Fluorinated Aliphatic Diazirines: Preparation, Characterization, and Photolabeling Studies

19 May 2022, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

The previously unknown difluoromethyl- and the previously neglected trifluoromethyl-aliphatic diazirines were synthesized and characterized. Model photolabeling experiments and biological studies revealed that the stable trifluoromethyl-aliphatic diazirines could indeed be safely used as photoaffinity labels, while the labile difluoromethylated analogues - could not.

Keywords

fluorine
diazirines
amines
Photolabeling
medicinal chemistry

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Now Published

Fluorinated Aliphatic Diazirines: Preparation, Characterization, and Model Photolabeling Studies [opens in a new tab]
Yurii Kornii, Oleg Shablykin, Taras Tarasiuk, Oleksandr Stepaniuk, Vitaliy Matvienko, Danylo Aloshyn, Nataliia Zahorodniuk, Iryna V. Sadkova, Pavel K. Mykhailiuk journal article
The Journal of Organic Chemistry , Volume 88, Issue 1
Online publication date: Nov 18, 2022

Version History

May 19, 2022 Version 1

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The content is available under CC BY 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2022-n5xbv
D O I: 10.26434/chemrxiv-2022-n5xbv [opens in a new tab]

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) declare that they have sought and gained approval from the relevant ethics committee/IRB for this research and its publication.

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