Organic Chemistry

Fluorinated Aliphatic Diazirines: Preparation, Characterization, and Photolabeling Studies

Authors

Abstract

The previously unknown difluoromethyl- and the previously neglected trifluoromethyl-aliphatic diazirines were synthesized and characterized. Model photolabeling experiments and biological studies revealed that the stable trifluoromethyl-aliphatic diazirines could indeed be safely used as photoaffinity labels, while the labile difluoromethylated analogues - could not.

Content

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Supplementary material

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SI
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