At present, the biggest challenge for the development of organic electronic devices is the uncontrollable molecular structure of organic materials. For small molecule organic electronic materials, due to the lack of design, the arrangement between molecules is often uncontrollable and the formed crystals lack thermal stability. For polymer electronic materials, it is difficult to form ordered lattice, which greatly limits the improvement of its mobility. In this paper, we first proposed the strategy of ‘adjacent molecules can be locked to each other’ (TML) and designed and synthesized a TML molecule with bio-simulating the structure of DNA. Experiments show that TML molecules have good thermodynamic stability and electron beam radiation robustness. PL Spectrum and calculation verified that TML molecules had strong electron coupling, revealing its application potential in organic electronics. More importantly, TML molecules verify the feasibility of bottom-up construction of all-crystalline organic electronic materials.