Dynamics and biomedical application of novel superparamagnetic helical nanorobots


The magnetic nanorobots, primarily composed of ferromagnetic materials, have been extensively investigated for their potential applications in cellular diagnostics and therapy. However, because of the substantial magnetic remanence exhibited by ferromagnetic materials, the magnetic stability of these nanorobots is a matter of serious concern. Here, we have designed and developed superparamagnetic iron oxide nanoparticles’(SPIONs) functionalized nanorobots (SPIONs-NR), a unique system that is highly stable against magnetic agglomeration. This kind of arrangement of random magnetic moments adhering to the nanorobot’s surface is relatively new and has not been previously explored in terms of fundamental physics and biomedical applications. We have carefully analyzed the various dynamical aspects of these functionalized nanorobots by studying their precession angle as a function of applied frequency at different magnetic fields. Furthermore, these functionalized nanorobots can be controllably maneuvered in the extracellular matrix by the application of rotating magnetic fields of comparatively lower magnitudes (usually < 50 G) to selectively target and annihilate malignant tissues via magnetic hyperthermia-induced localized heating, and therefore, making SPIONs-NR promising candidates in modernizing advanced nanomedicine research.