Organic Chemistry

Activation of Alkyl Chlorides Enabled by Zirconocene and Photoredox Catalysis



C–Cl bond cleavage of unactivated alkyl chlorides with zirconocene and photoredox catalysis has been achieved. The present protocol exhibited a broader scope of alkyl chlorides compared to the preceding methods with titanocene. This scope expansion could be attribut-ed to the zirconium metal center rendering the C–Cl bond cleavage more endergonic and lowering the transition states.


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Supplementary material

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Supporting Information
Supporting Information

Supplementary weblinks

Yamaguchi Group
J. Yamaguchi group website