- Cui-Lian Liu Université Catholique de Louvain ,
- Eduard Bobylev University of Amsterdam ,
- Brice Kauffmann University of Bordeaux ,
- Koen Robeyns universite catholique de louvain ,
- Yann Garcia Université Catholique de Louvain ,
- Joost Reek University of Amsterdam ,
- Michael Singleton Université Catholique de Louvain
Non-covalent interactions play an essential role in the folding and self-assembly of large biological assemblies. These interactions are not only a driving force for the formation of large structures but also control conformation and com-plementary shapes of subcomponents that promote the diversity of structures and functions of the resulting assemblies. Understanding how non-covalent interactions direct self-assembly and the effect of conformation and complementary shapes on self-assembled structures will help design artificial supramolecular systems with extended components and functions. Herein, we develop a strategy for controlling more complex self-assembly with lower symmetry and flexible building blocks that combine endohedral non-covalent interactions with a dual curvature in the ligand backbone to give additional shape complementarity. A Diels-Alder reaction was used to break the symmetry of the diazaanthracene units of the ligands to give dual curvature ligands with different shapes and endohedral groups (L1-L3). The self-assembly studies of these ligands demonstrated that non-covalent interactions and shape complementary effectively control the self-assembly and enable the design of cages for supramolecular catalysis.
Solvent optimization and additional control experiments with mononuclear Pd2+ complexes and salts were performed for the catalytic studies using the self-assembled cages. Synthesis of the control complexes and isolation/purification of the cages was added. The manuscript and the SI have been updated to include a description of these results.