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Selective reductions of ketones in the presence of aldehydes with Chiralidon a superabsorbed alcohol dehydrogenase - a "green" metal free alternative to the Luche-reduction

05 May 2022, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

The selective reduction of a keto group in the presence of an aldehyde group with a superabsorbed alcohol dehydrogenase in an organic solvent is described. Remarkably a high preference for the reduction of the keto group was found. For example the 4-acetylbenzaldehyde was reduced with Chiralidon-R to the chiral alcohol (R)-1-(4-formylphenyl)ethanol with 96.5% yield.

Keywords

Acetylbenzaldehyde
superabsorbed alcohol dehydrogenase
Chiralidon
selective reductions
Luche-reduction

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Version History

May 05, 2022 Version 1

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The content is available under CC BY 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2022-hthz6
D O I: 10.26434/chemrxiv-2022-hthz6 [opens in a new tab]

Funding

Kompetenzplattform Bioengineering Jülich, financed by the Ministry for Innovation, Science, Research and Technology of North-Rhine Westphalia
Dr. Sönke Petersen http://syntheselabor.de

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

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