Organic Chemistry

Selective reductions of ketones in the presence of aldehydes with Chiralidon a superabsorbed alcohol dehydrogenase - a "green" metal free alternative to the Luche-reduction



The selective reduction of a keto group in the presence of an aldehyde group with a superabsorbed alcohol dehydrogenase in an organic solvent is described. Remarkably a high preference for the reduction of the keto group was found. For example the 4-acetylbenzaldehyde was reduced with Chiralidon-R to the chiral alcohol (R)-1-(4-formylphenyl)ethanol with 96.5% yield.


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