Strategic Enzymatic Transformations in Modern Natural Product Synthesis


  • Felix Kaspar Technische Universität Braunschweig & Technical University of Berlin ,
  • Anett Schallmey Technische Universität Braunschweig


Enzymes continue to gain recognition as valuable tools in synthetic chemistry as they enable transformations, which elude conventional organochemical approaches. As such, the progressing expansion of the biocatalytic arsenal has introduced unprecedented opportunities for new synthetic strategies and retrosynthetic disconnections. As a result, enzymes have found a solid foothold in modern natural product synthesis for applications ranging from the generation of early chiral synthons to endgame transformations, convergent synthesis and cascade reactions for the rapid construction of molecular complexity. As a primer to the state-of-the-art concerning strategic uses of enzymes in natural product synthesis and the underlying concepts, this review highlights selected recent literature examples (covering 2020 to April 2022), which make a strong case for the admission of enzymatic methodologies into the standard repertoire for complex small molecule synthesis.


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