Ni-Catalyzed Enantioselective Dialkyl Carbinol Synthesis via Decarboxylative Cross Coupling: Development, Scope, and Applications



The first enantioselective decarboxylative Negishi-type alkylations of a-oxy carboxylic acids is reported via the intermediacy of redox-active esters (RAEs). This transformation enables a radical-based retrosynthesis of seemingly trivial enantiopure dialkylcarbinols. This article includes a discussion of the history of such couplings, the retrosynthetic ramifications of such a coupling, the development of general conditions, and an extensive series of applications that vividly demonstrate how it can simplify synthesis.


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Supplementary material

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supporting information
The Supporting Information contains all experimental procedures, analysis, and compound characterization data.