Ni-Catalyzed Enantioselective Dialkyl Carbinol Synthesis via Decarboxylative Cross Coupling: Development, Scope, and Applications

28 April 2022, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


The first enantioselective decarboxylative Negishi-type alkylations of a-oxy carboxylic acids is reported via the intermediacy of redox-active esters (RAEs). This transformation enables a radical-based retrosynthesis of seemingly trivial enantiopure dialkylcarbinols. This article includes a discussion of the history of such couplings, the retrosynthetic ramifications of such a coupling, the development of general conditions, and an extensive series of applications that vividly demonstrate how it can simplify synthesis.


decarboxylative coupling
asymmetric synthesis
radical chemistry
nickel catalysis
organic synthesis

Supplementary materials

supporting information
The Supporting Information contains all experimental procedures, analysis, and compound characterization data.


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