Ni-Catalyzed Enantioselective Dialkyl Carbinol Synthesis via Decarboxylative Cross Coupling: Development, Scope, and Applications

Abstract

The first enantioselective decarboxylative Negishi-type alkylations of a-oxy carboxylic acids is reported via the intermediacy of redox-active esters (RAEs). This transformation enables a radical-based retrosynthesis of seemingly trivial enantiopure dialkylcarbinols. This article includes a discussion of the history of such couplings, the retrosynthetic ramifications of such a coupling, the development of general conditions, and an extensive series of applications that vividly demonstrate how it can simplify synthesis.

Content

Supplementary material

supporting information
The Supporting Information contains all experimental procedures, analysis, and compound characterization data.