Unexpected isomerization of oxetane-carboxylic acids

26 April 2022, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

We unexpectedly discovered that popular oxetane-carboxylic acids are intrinsically unstable. They easily isomerize into lactones under storage at rt, or under slight heating. Chemists should keep in mind the high instability of these common molecules, as this could dramatically affect the reaction yields and lead to negative results (especially in those reactions that require heating).

Supplementary materials

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Title
Unexpected isomerization of oxetane-carboxylic acids
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