Organic Chemistry

Unexpected isomerization of oxetane-carboxylic acids

Authors

Abstract

We unexpectedly discovered that popular oxetane-carboxylic acids are intrinsically unstable. They easily isomerize into lactones under storage at rt, or under slight heating. Chemists should keep in mind the high instability of these common molecules, as this could dramatically affect the reaction yields and lead to negative results (especially in those reactions that require heating).

Content

Thumbnail image of 220425_Oxetanes_cleavage.pdf

Supplementary material

Thumbnail image of 220421_SI.pdf
Unexpected isomerization of oxetane-carboxylic acids
Supporting Information