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Abstract
The site-selective palladium-catalyzed three-component coupling of unactivated alkenyl carbonyl compounds, aryl- or alkenylboronic acids, and N-fluorobenzenesulfonimide is described herein. Tuning of the steric environment on the bidentate directing auxiliary is proposed to facilitate challenging C(sp3)–F reductive elimination from a Pd(IV) intermediate to afford 1,2-carbofluorination products in good yields and with high regioselectivity.
Supplementary materials
Title
Supporting Info
Description
experimental procedures, characterization data for new compounds, copies of NMR spectra, and X-ray crystal structure data
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Title
CIF_S-3
Description
crystallographic information file for compound S-3
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