Deuteron-decoupled singlet NMR in low magnetic fields: Application to the hyperpolarization of succinic acid

12 April 2022, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


The reaction of unsaturated substrates with hydrogen gas enriched in the para spin isomer leads to products with a high degree of nuclear singlet spin order. This leads to greatly enhanced NMR signals, with important potential applications such as magnetic resonance imaging (MRI) of metabolic processes. Although parahydrogen-induced polarization has the advantage of being cheap, compact, and mobile, especially when performed in ultralow magnetic fields, efficiency is lost when more than a few protons are involved. This strongly restricts the range of compatible substances. We show that these difficulties may be overcome by a combination of deuteration with the application of a sinusoidally modulated longitudinal field as a well as a transverse rotating magnetic field. We demonstrate a six-fold enhancement in the 13C hyperpolarization of [1-13C, 2,3-d2]-succinic acid, as compared with standard hyperpolarization methods, applied in the same ultralow field regime.


para-hydrogen induced polarization
nuclear singlet state

Supplementary materials

Supporting Information
Supporting information includes explicit sketch of the experimental setup, theoretical describtion of the work, numerical simulatations and experimental optimization for procedures performed.


Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.