Biological and Medicinal Chemistry

Solvent-free Synthesis of polymethoxy and dichloro p-nitrophenyl hydrazones

Authors

Abstract

A solvent-free method for the synthesis of novel p-nitrophenyl hydrazones was successfully developed. The condensation of the p-nitrophenyl hydrazine with aromatic aldehydes through this mechanochemical technique furnished three products (3a-c) with moderate to high yield. The developed method is eco-friendly, efficient, simple, and convenient and indicated high reproducibility, short reaction time, catalyst-free, simple workup, and afforded pure and unsolvated products.

Content

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Supplementary material

Thumbnail image of SUPPLEMENTARY INFORMATION SF.docx
FTIR, 1D, and 2D spectra of the synthesized compounds.
The supplematery material contain fully elucidated proton and carbon-13 spectra of the synthesized compounds. In addition, elucidated COSY, HSQC, and HMBC spectra for each of the compounds are included.