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Protein corona alters the mechanisms of interaction between silica nanoparticles and lipid vesicles

08 April 2022, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

We investigate the impact of a bovine serum albumin corona on interactions between silica nanoparticles (SNPs) of two different sizes and giant lipid vesicles. The protein corona alters the morphological response of vesicles to SNPs, demonstrating that a protein corona can change the interaction mechanism between nanoparticles and lipid membranes.

Keywords

Giant Unilamellar Vesicles
Bovine serum albumin
Confocal microscopy
Nanoparticle-membrane interactions
Vesicle morphology
Protein corona

Supplementary materials

Title
Description
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Title
Supplementary information - methods and supporting data
Description
Detailed methods. TEM characterisation of the nanoparticles. DLS and zeta potential characterisation of the nanoparticles. BSA-only control experiment with GUVs.
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Version History

Apr 08, 2022 Version 1

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The content is available under CC BY 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2022-2xwnv
D O I: 10.26434/chemrxiv-2022-2xwnv [opens in a new tab]

Funding

University of Leeds

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

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