A Concise Biocatalytic Synthesis of Pretomanid

Yuxuan Ye; Todd Hyster

doi:10.26434/chemrxiv-2022-3ngrf

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A Concise Biocatalytic Synthesis of Pretomanid

Working Paper

Yuxuan Ye Cornell University ,
Todd Hyster Cornell University

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Abstract

An efficient protocol to produce Pretomanid is proposed and studied. The stereodetermining step of the proposed synthesis a ketone reduction by a ketoreductase. However, the unexpected stability of the ketal intermediate.

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Supplementary material

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NMRs and Procedures

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Mar 31, 2022 Version 1

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The content is available under CC BY NC ND 4.0 License CreativeCommons.org

DOI

10.26434/chemrxiv-2022-3ngrf

Funding

Bill and Melinda Gates Foundation

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

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The author(s) declare that they have sought and gained approval from the relevant ethics committee/IRB for this research and its publication.

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This content is an early or alternative research output and has not been peer-reviewed at the time of posting.

A Concise Biocatalytic Synthesis of Pretomanid

Authors

Abstract

Content

Supplementary material

Version History

Metrics

License

DOI

Funding

Author’s competing interest statement

Ethics

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