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A Concise Biocatalytic Synthesis of Pretomanid

31 March 2022, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

An efficient protocol to produce Pretomanid is proposed and studied. The stereodetermining step of the proposed synthesis a ketone reduction by a ketoreductase. However, the unexpected stability of the ketal intermediate.

Supplementary materials

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NMRs and Procedures
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Version History

Mar 31, 2022 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2022-3ngrf
D O I: 10.26434/chemrxiv-2022-3ngrf [opens in a new tab]

Funding

Bill and Melinda Gates Foundation

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) declare that they have sought and gained approval from the relevant ethics committee/IRB for this research and its publication.

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