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Abstract
We describe the development of bis-guanidinium-based synthetic chloride-phosphate ion carriers. Photoinduced generation of the active anionophore from proanionophore enhanced the transport of chloride-phosphate ions across the lipid bilayers and promoted cancer (HeLa) cell death. Such photoactivatable chloride-phosphate antiporters could be helpful to develop iontherapy to treat cancer and other diseases.
Supplementary materials
Title
Photoinduced generation of the active chloride-phosphate anionophore from its inactive proanionophore
Description
Synthesis, characterization, biophysical and biological studies
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