Solution aggregation of two carbamazepine co-crystal systems as indication of nucleation pathways

11 March 2022, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

An investigation into the solution phase aggregation of carbamazepine/saccharin and carbmazepine/nicotinamide shows weak and strong interaction, respectively, though both systems co-crytallise easily. The strong self-aggregation of saccharin molecules restricts the interaction between carbamazepine and saccharin. The strength of interaction can be connected to different nucleation pathways.

Keywords

solution aggregation
NMR spectroscopy
binding constants
nucleation

Supplementary materials

Title
Description
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Title
Solution aggregation of two carbamazepine co-crystal systems as indication of nucleation pathways - ESI
Description
Supplementary figures and experimental section to the main manuscript.
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