Silver Trifluoroacetate Promoted Cycloisomerization of 3,5-diyn-1-ones: the direct observation of Ag intermediate and their application in synthesis

Authors

  • Yu He University of Chinese Academy of Sciences ,
  • Li Xiuming University of Chinese Academy of Sciences ,
  • Hong Tianyu University of Chinese Academy of Sciences ,
  • Yang Jing-Kui University of Chinese Academy of Sciences

Abstract

A simple and mild method for silver trifluoroacetate promoted cycloisomerization of 3,5-diyn-1-ones provided 2-alkynyl furans, which can be further transformed into alkyne hydration or furan-based polycyclic products was developed. It was found that tri-fluoroacetate anion plays a crucial role in the cycloisomerization reaction, and the intermediate Ag-furan complex was first directly observed by 1H-NMR spectroscopy and mass spectrometry.

Content

Supplementary material

SI-Silver Trifluoroacetate Promoted Cycloisomerization of 3,5-diyn-1-ones the direct observation of Ag intermediate and their application in synthesis
SI for Silver Trifluoroacetate Promoted Cycloisomerization of 3,5-diyn-1-ones the direct observation of Ag intermediate and their application in synthesis