Working Paper
Authors
- Arnau Rodríguez-Rubio University of Southampton ,
- Andrea Savoini University of Southampton ,
- Florian Modicom University of Southampton ,
- Patrick Butler University of Southampton ,
- Stephen Goldup
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University of Southampton
Abstract
As recognized in the early 1960s, catenanes composed of two achiral rings that are oriented (Cnh symmetry) as a result of the sequence of atoms they contain are topologically chiral. Here we present the first synthesis of a highly enantioenriched catenane containing a related but overlooked “co-conformationally ‘topologically’ chiral” stereogenic unit, which arises when a bilaterally symmetric Cnv ring is desymmetrised by the position of an oriented macrocycle.
Content
Supplementary material
Electronic supporting information
Supporting information including characterisation data for all novel compounds and extended discussion
cif for rac-(S,Smt)-3b
crystallographic data for rac-(S,Smt)-3b
cif for rac-6
crystallographic data for rac-6
cif for rac-9
crystallographic data for rac-9
