Visible-Light Driven Enantioselective Radical Addition to Imines Ena-bled by Excitation of Chiral Phosphoric Acid–Imine Complex

14 February 2022, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


A visible-light driven enantioselective radical addition to imines enabled by the direct excitation of a chiral phosphoric acid-imine complex was developed. By using benzothiazolines as the radical precursors, chiral amine products were obtained with high enantioselectivities (up to 98% ee). Mechanistic studies elucidated that the chiral phosphoric acid-imine complex has photoredox activities for oxidizing benzothiazolines.


enantioselective reaction
chiral phosphoric acid
radical addition

Supplementary materials

Supporting Information
Additional experimental details and characterization data for new compounds


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