Organic Chemistry

Construction of a Reduction-responsive DNA Microsphere using a Reduction-cleavable Spacer based on a Nitrobenzene Scaffold



We describe that the reduction-cleavable spacer (RCS) containing a nitrobenzene scaffold can be incorporated into a single-stranded DNA sequence to enable the construction of a reduction-responsive DNA architecture with spherical morphology at micrometer scale. The RCS could allow for the introduction of the reduction-responsiveness into various functional oligonucleotides as well as nucleic acid-based architectures.


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Supplementary material

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Supporting information
The supporting information contains a detailed description of the experiments and additional data (Fig. S1-S6).