How very small changes in the peptide sequence of β-amyloids influence their redox properties. Electrochemical studies of Aβ(11-16) and pAβ(11-16) in two different electrolytes.

08 February 2022, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Here we demonstrate a significant difference in redox behaviour of copper complexes with β-amyloids Aβ(11-x) and pAβ(11-x) which are models for important components of senile plaques. A small change in the peptide chain may enhance reactive oxygen species (ROS) formation which can severely damage nerve cells.

Keywords

Alzheimer's disease
Amyloid-β peptides
Voltammetry
Copper complexes
Pyroglutamate-modified Amyloid-β

Supplementary materials

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Additional electrochemical data
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Additional electrochemical data and experimental details.
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