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Visible-light enabled C(sp3)–C(sp2) cross-electrophile coupling via synergistic nickel and halogen-atom transfer (XAT) catalysis

28 January 2022, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

We herein report the first visible-light-mediated cross-coupling of unactivated alkyl iodides with aryl bromides through synergistic nickel and halogen atom transfer (XAT) catalysis. This simple protocol operates under mild reaction conditions and tolerates variety of functional groups affording C(sp3)–C(sp2) cross-coupling products in good to moderate yields.

Keywords

Visible light
cross-coupling
halogen atom transfer
Iodo alkanes
Aryl bromides

Supplementary materials

Title
Description
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Title
Visible-light enabled C(sp3)–C(sp2) cross-electrophile coupling via synergistic nickel and halogen-atom transfer (XAT) catalysis
Description
Details on experimental procedures, characterization, and NMR spectra of cross-coupling products and crystal data of 7.
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Version History

Jan 28, 2022 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2022-1tv13
D O I: 10.26434/chemrxiv-2022-1tv13 [opens in a new tab]

Funding

Science and Engineering Research Board
SRG/2021/000834

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

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