In this paper, we present a generalizable method for the fabrication of disposable spectrofluidic devices for solution characterization by attenuated total reflectance (ATR) Fourier transform infrared (FTIR) spectroscopy. A major design feature is the integration of an ATR element into the device rather than the fabrication of the microchannels on its sensing surface. This alleviates spatial limitations, due to small element footprint and dominance of edge-beading, enabling arbitrarily complex microfluidic circuitry and complex world-to-chip interfaces while leaving the entire ATR element available for sensing. An optimized optical interface maximizes light transfer into the on-chip sensing chamber. This promotes low limits of detection, fast measurements and/or designs featuring multiple sensing sub regions. To demonstrate the approach, we conducted measurements on complex flow profiles generated from four separate proof-of-concept spectrofluidic devices. A high sensitivity device detected glucose and sodium phosphate dibasic(Na2HPO4) at concentrations as low as 3 mM and 1 mM, respectively or and for time-lapse results with second-scale time resolution from single-scan measurements. We also demonstrated spatial selectivity for assays in parallel channels, measurements of concentration gradients in a multi-laminar co-flow device, and monitored fast kinetics of the protonation of a pH buffer in a microfluidic reactor.