Working Paper
Authors
- Sonja Srdanovic University of Leeds ,
- Zsofia Hegedus University of Szeged ,
- Stuart Warriner University of Leeds ,
- Wilson Andrew
University of Leeds
Abstract
Using the hDMX/14-3-3 interaction, acylhydrazone-based ligand-directed fragment ligation was used to identify protein-protein interaction (PPI) inhibitory peptide-fragment hybrids. Separation of the peptide-fragment hybrids into the components yielded fragments that stabilized the hDMX/14-3-3 interaction.
Content

Supplementary material

supporting data and figures
supporting data, figures, methods and characterization