Biological and Medicinal Chemistry

Towards Identification of Protein-Protein Interaction Stabilizers via Inhibitory Peptide-Fragment Hybrids Using Templated Fragment Ligation



Using the hDMX/14-3-3 interaction, acylhydrazone-based ligand-directed fragment ligation was used to identify protein-protein interaction (PPI) inhibitory peptide-fragment hybrids. Separation of the peptide-fragment hybrids into the components yielded fragments that stabilized the hDMX/14-3-3 interaction.


Thumbnail image of DLS for stabilizers ChemRxiv Manuscript 13-01-22.pdf

Supplementary material

Thumbnail image of DLS for stabilizers ChemRxiv Supporting Information 13-01-22.pdf
supporting data and figures
supporting data, figures, methods and characterization