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Dearomative Michael addition involving enals and 2-nitrobenzofurans realized under NHC-catalysis

12 January 2022, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

In the manuscript the first enantioselective dearomative Michael addition between α,β-unsaturated aldehydes and 2-nitrobenzofurans realized under N-heterocyclic carbene activation has been described. The reaction proceeds via addition of homoenolate to Michael acceptors leading to the formation of biologically important heterocycles with high yields and stereoselectivities. Their functionalization potential has been confirmed in selected, diastereoselective transformations.

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Version History

Jan 12, 2022 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2022-jktz4
D O I: 10.26434/chemrxiv-2022-jktz4 [opens in a new tab]

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

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