Materials Science

Lipid-Head-Polymer-Tail Chimeric Nanovesicles

Authors

  • Kan Hu University of Science and Technology of China ,
  • Aoyuan Cheng University of Science and Technology of China ,
  • Dingcheng Zhou University of Science and Technology of China ,
  • Yi Luo University of Science and Technology of China ,
  • Guoqing Zhang University of Science and Technology of China

Abstract

Lipid nanovesicles (LNVs) and polymer nanovesicles (PNVs), also known as liposomes and polymersomes, are becoming increasingly vital in global health. One recent example is the widely distributed mRNA Covid-19 vaccines. However, the two major classes of nanovesicles both exhibit their own issues that significantly limit potential applications. Here, by covalently attaching a naturally occurring phosphate “lipid head” and a synthetic polylactide “polymer tail” via facile ring-opening polymerization on a 500-gram scale, a type of “chimeric” nanovesicles (CNVs) can be easily produced. Compared to LNVs, the reported CNVs exhibit reduced permeability for small and large molecules; on the other hand, the CNVs are less hydrophobic and exhibit enhanced tolerance toward proteins in buffer solutions without the need for hydrophilic polymeric corona such as poly(ethylene glycol), in contrast to conventional PNVs. The proof-of-concept in vitro delivery experiments using hydrophilic solutions of fluorescein-PEG, rhodamine-PEG, and anti-cancer drug doxorubicin demonstrate that these CNVs, as a structurally diverse class of nano-materials, are highly promising as alternative carriers for therapeutic molecules in translational nanomedicine.

Content

Thumbnail image of Hu_CNVs_2022 _MS(2).pdf

Supplementary material

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Lipid-Head-Polymer-Tail Chimeric Nanovesicles
Liposomes and polymersomes are becoming increasingly vital in global health. However, the two major classes of nanovesicles exhibit their own issues that significantly limit potential applications. Here, by covalently attaching a naturally occurring phosphate “lipid head” and a synthetic polylactide “polymer tail” via facile ring-opening polymerization on a 500-gram scale, a type of “chimeric” nanovesicles (CNVs) can be easily produced with high vesicle-forming yields using the material. Compared to the LNVs, the CNVs exhibit reduced permeability for small and large molecules; on the other hand, the CNVs are less hydrophobic and exhibit enhanced tolerance toward proteins in buffer solutions without the need for hydrophilic corona such as poly(ethylene glycol), in comparison with PNVs. The proof-of-concept in vitro delivery experiments using hydrophilic fluorescein-PEG, hydrophobic Sudan Red, and anti-cancer drug doxorubicine demonstrate that these CNVs, as a structurally diverse class of nano-materials, are highly promising as carriers for therapeutic molecules in nanomedicine.